If it is the Sedgewick Hotel you would like to visit, you are out of luck. The place where the Ghostbusters first encounter Slimer, does not exist under that name. The hotel that was used for the film is actualy the “Biltmore Hotel” at South Grand Avenue. Good luck hunting down the Slimer ghost! http://www.millenniumhotels.com/usa/millenniumbiltmorelosangeles/
In 1984, Ivan Reitman and his crew used a lot of New York locations for their “Ghostbusters” movie. Perhaps the most famous one is the small fire station, which is actualy very real. It is located at 14 North Moore Street. However, the interior was not filmed in New York, but in downtown Los Angeles.